Asian Journal of Pharmacy and Technology

K. Pramod ¹, Shahid H. Ansari ², Javed Ali ¹

Affiliations
1 Department of Pharmaceutics, Faculty of Pharmacy, Jamia Hamdard, Hamdard Nagar, New Delhi–110062, IN
2 Department of Pharmacognosy & Phytochemistry, Faculty of Pharmacy, Jamia Hamdard, Hamdard Nagar, New Delhi – 110062, IN

Abstract

A good number of manuscripts are being published where the authors carry out qualitative assessment of the region of interest in the phase diagrams. These qualitative assessments can be sensed as a lack of sound technique for quantitative assessment. In the present technical note we have developed a simple cut and weigh method to offer a quantitative method for assessing phase diagrams. The method was validated and explained using sample analysis. The method was found to be robust, quantitative and enabled statistical comparison of the results. The method was found to be excellent even when applied for samples below a weight of 10 mg and that too on different paper sheets. The suggested technique of expressing the result as a percentage of the total area could offer a universal applicability of the method for assessment of phase diagrams. The developed and validated method would be a great tool for the researchers requiring quantitative assessment of phase diagrams.

Keywords

Nanoemulsion, Microemulsion, Validation, p value

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M. Karthika ¹, K. Pramod ¹, K. C. Ajithkumar ², U. S. Jijith ²

Affiliations
1 College of Pharmaceutical Sciences, Govt. Medical College, Thiruvananthapuram – 695011, Kerala, IN
2 College of Pharmaceutical Sciences, Govt. Medical College, Kozhikode - 673008, Kerala, IN

Abstract

Nanodiamonds are nano-sized carbon based particles coming under the family of nanocarbons. Since nanodiamonds have ability to emit bright fluorescence, they were used primarily as biological imaging agents after the introduction of nitrogen defects. These are now widely used because of their inexpensive large-scale synthesis, small particle size, and high biocompatibility. Its large surface area, high absorption capacity and chemical inertness were made advantageous to use as potential medical agents. Nanodiamonds are carbon allotropes of approximately 2 to 8 nm in diameter. Surface of each nanodiamond possess functional groups for wide spectrum of compounds. Nanodiamonds have the acceptable properties includes hardness, chemical inertness, surface area, solubility, optical properties and allows chemical modification. Its large surface area provides space for loading of drug by adsorption. By this mechanism, it is easy to create smart environment-and stimuli-responsive nanodiamond drug delivery and release system. It can be also used for bioimaging, localised chemotherapeutic drug delivery, improving image resolution of MRI, insulin administration and used in Skin and dental care preparation and cosmetics. As nanodiamond drug delivery is an emerging and growing concept, it will gaining more attraction by industries and many research scientists due to its wide potential and acceptance.

Keywords

Adsorption, Cancer, Graphite, Nanodiamonds, Nanoparticles.

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M. Nagajyothi ¹, K. Pramod ¹, E. N. Bijin ¹, Jomon N. Baby ¹, J. Valsalakumari ¹

Affiliations
1 College of Pharmaceutical Sciences, Govt. Medical College, Thiruvananthapuram-695011, Kerala, IN

Abstract

Accelerated stability studies were carried out according to ICHQ1A (R2) guidelines. For drug products intended to be stored at room temperature, the accelerated stability studies are to be carried out at controlled temperature and humidity conditions of 40 ± 2°C and humidity 75 ± 5% RH. Results from stability studies indicated stability of atorvastatin loaded nanoemulsion gel formulation, as there was no significant change in observed physical parameters. The shelf life of nanoemulsion gel was found to be 19.23 months. The study conducted therefore substantiated the stability of atorvastatin loaded nanoemulsion gel.

Keywords

Nanoemulsion Gel, Atorvastatin, Shelf Life.

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